The following is a list of mayors of Roanoke, Virginia. This list includes the mayors of the former town Big Lick, Virginia, which was later incorporated as the city of Roanoke on February 3, 1882.
Mayors of the town of Big Lick:
| No. | Name | Entered office | Left office |
|---|---|---|---|
| 1 | John Trout | February 28, 1874 | June 30, 1876 |
| 2 | Samuel Griggs | July 1, 1876 | June 30, 1878 |
| 3 | William H. Startzman | July 1, 1878 | June 30, 1880 |
| 4 | Marshall Waid | July 1, 1880 | February 3, 1882 |
Elected mayors following incorporation as the City of Roanoke:
| No. | Name | Entered office | Left office |
|---|---|---|---|
| 5 | Marshall Waid | February 3, 1882 | June 30, 1892 |
| 6 | Lucian H. Cocke | July 1, 1882 | June 30, 1884 |
| 7 | John H. Dunston | July 1, 1884 | June 30, 1885 |
| 8 | Samuel G. Williams | July 1, 1885 | June 30, 1886 |
| 9 | William Carr | July 1, 1886 | June 30, 1890 |
| 10 | William G. Evans | July 1, 1890 | June 30, 1892 |
| 11 | Henry S. Trout | July 1, 1892 | June 30, 1894 |
| 12 | Sturgis E. Jones | July 1, 1894 | June 30, 1896 |
| 13 | Robert McClelland | July 1, 1896 | November 2, 1896 |
| 14 | William K. Andrews | November 2, 1896 | June 30, 1898 |
| 15 | James P. Woods | July 1, 1898 | June 30, 1900 |
| 16 | J. Randolph Bryan | July 1, 1900 | February 13, 1902 |
| 17 | Robert D. Buckner | February 13, 1902 | June 30, 1902 |
| 18 | Joel H. Cutchin | July 1, 1902 | April 9, 1912 |
| 19 | Sylvester P. Seifert | April 9, 1912 | June 30, 1912 |
| 20 | John M. Woods | July 1, 1912 | December 23, 1912 |
| 21 | Charles B. Mooman | February 1, 1913 | October 18, 1915 |
| 22 | Charles M. Brown | October 18, 1915 | August 31, 1918 |
| 23 | W.W. Boxley | September 1, 1915 | August 31, 1922 |
| 24 | Blair J. Fishburn | September 1, 1922 | August 31, 1926 |
| 25 | Charles D. Fox | September 1, 1926 | August 31, 1930 |
| 26 | Sylvester P. Seifert | September 1, 1930 | August 31, 1934 |
| 27 | Sidney F. Small | September 1, 1934 | June 2, 1938 |
| 28 | James A. Bear | June 2, 1938 | August 31, 1938 |
| 29 | Walter W. Waid | September 1, 1938 | October 15, 1943 |
| 30 | Leo F. Henebry | October 15, 1943 | August 31, 1946 |
| 31 | Richard T. Edwards | September 1, 1946 | August 31, 1948 |
| 32 | Williams P. Hunter | September 1, 1948 | August 31, 1949 |
| 33 | Roy L. Webber | September 1, 1949 | August 31, 1954 |
| 34 | Robert W. Woody | September 1, 1954 | August 31, 1956 |
| 35 | Walter L. Young | September 1, 1956 | August 31, 1958 |
| 36 | Vincent S. Wheeler | September 1, 1958 | August 31, 1960 |
| 37 | Wills M. Anderson | September 1, 1960 | August 31, 1962 |
| 38 | Murray A. Stoller | September 1, 1962 | August 31, 1964 |
| 39 | Benton O. Dillard | September 1, 1964 | August 31, 1968 |
| 40 | Roy L. Webber | September 1, 1968 | October 18, 1975 |
| 41 | Noel C. Taylor | October 27, 1975 | June 30, 1992 |
| 42 | David Bowers | July 1, 1992 | June 30, 2000 |
| 43 | Ralph K. Smith | July 1, 2000 | June 30, 2004 |
| 44 | Nelson Harris | July 1, 2004 | June 30, 2008 |
| 45 | David Bowers | July 1, 2008 | Incumbent |